The Gut-Histamine Connection: Why I’m Starting a 60-Day Gut Protocol
Last week, I shared my journey with histamine intolerance—how certain meals were wrecking my sleep, leaving me wired at night, foggy in the morning, and wondering what was going on inside my body.
What I didn’t realise at the time was that the real issue wasn’t just the food. It was my gut.
“But I Eat So Clean…”
Like many men in midlife who care about their health, I’ve put in the work:
No ultra-processed food
No seed oils, refined sugar, or grains (except rice)
No alcohol or smoking
Clean environment, low toxin exposure
And still… something felt off.
That’s the frustrating thing.
You can tick all the “healthy lifestyle” boxes, but if your gut ecosystem is out of balance, it can silently throw everything else off—your sleep, mood, energy, hormones, immunity, and yes… even histamine.
What My Partner’s Test Revealed (And Why It Affects Me Too)
My partner has been feeling off for a while—achy joints, brain fog, low energy, and some persistent gut symptoms. So, she did the smart thing and worked with a Functional Medicine Practitioner to run a comprehensive stool test.
The results? Gut dysbiosis and a parasite.
And here’s what most people don’t realise: When you share a home and a bed, you often share microbes too. If your partner has gut dysbiosis or a parasite, there’s a good chance you do too.
Which is why I’ve decided to go all-in on a 60-day gut protocol to reset and rebuild my own gut health—because I now believe my histamine issues (and restless nights) are rooted in my gut.
What Does the Gut Have to Do With Histamine?
Here’s the big connection: Your gut microbiome plays a massive role in producing, degrading, and regulating histamine.
Certain gut bacteria (especially some in the Firmicutes phylum) can produce histamine.
Others help break it down—but if they’re missing, histamine can build up.
A leaky or inflamed gut can lower levels of DAO, the enzyme that clears histamine from the body.
Parasites and pathogens can activate mast cells, triggering even more histamine release.
So if your gut is off, your histamine clearance system is likely compromised.
My Gut Protocol: Phase 1 – “Weed the Garden” (30-45days)
The first phase is about clearing out the overgrowth—like pulling weeds before you plant new seeds.
Here’s what I’m using:
NAC (N-acetyl cysteine)
1 cap, 30 mins before food
Supports gut lining + breaks down biofilms (protective layers around bad bugs) → BioMedica VegeNAC
Antimicrobials – 3x per day
MediHerb Myrrh Forte
BioCeuticals Clinical SI Complex → Targets parasites, harmful bacteria, and yeast
Charcoal binder – 30 mins after antimicrobials
→ Binds to toxins released during die-off so they don’t recirculate
Probiotic (S. boulardii) – 2 hours after binder → Rebuilds gut terrain, crowding out bad microbes → BioMedica SB Pro
Phase 2 – “Replant and Rebuild the Garden” (15-20 Days)
After clearing the space, it’s time to reintroduce beneficial microbes and repair the gut lining.
Here’s what that looks like:
High-dose probiotic → BioCeuticals UltraBiotic 500
Gut repair powder → Designs For Health GI-Revive (L-glutamine, zinc, marshmallow root, aloe, etc.) → Supports mucosal healing and tight junction repair
Taken together, this protocol is designed to:
Rebalance my gut microbiome
Reduce inflammation and histamine load
Support better digestion, immunity, and brain function
Improve sleep, mood, recovery, and overall energy
Why This Matters
Gut health isn’t just about bloating or digestion. It’s your control center—influencing your brain, hormones, immune system, and how well you handle stress.
And when it comes to histamine intolerance, the gut is often the missing link.
You can avoid histamine-rich foods all day long, but unless you support your gut’s ability to process and eliminate histamine, the problem will keep coming back.
What's Next?
I’ll be tracking symptoms like:
Sleep quality
Energy levels
Heart rate variability
Mood, focus, and clarity
Training recovery
And I’ll be sharing what I learn along the way. Because chances are, if you’re reading this and struggling with weird symptoms—there’s a gut piece to your puzzle too.
Stay tuned—I'll keep you posted on how things go. In the meantime, if you’ve ever felt off despite doing “everything right,” it might be time to look deeper… starting with your gut.
